2-aryl-5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4] diazepines

Details 2-aryl-5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4] diazepines 2-aryl-5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4] diazepines

C - Chemistry, Metallurgy

07

D

C07D 471/22 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2196136

Disclosed are novel 2-aryl-5,11-dihydro-6H-dipyrido- [3,2-b:2',3'-e] [1,4]diazepines. These are useful in the treatment of HIV infection. Exemplary compounds are: 8-Ethyl- 1-methyl-10-(4-pyrazolyl)imidazo[2',3':6,5]dipyrido[3,2-b:2',3'- e] [1,4]diazepine; 8-c-propyl-1-methyl-10-(4-pyrazolyl)imidazo- [2',3':6,5]dipyrido[3,2-b:2',3'-e] [1,4]diazepine 8-ethyl-12- methyl-10-(4-pyrazolyl)imidazo[2',3':6,5]dipyrido[[3,2-b:2',3'- e] [1,4]diazepine; and, 8-c-propyl-12-methyl-10-(4-pyrazolyl)- imidazo[2',3':6,5]dipyrido[3,2-b:2',3'-e][1,4]diazzepine.

ont présentées de nouvelles 2-aryle-5,11-dihydro-6H-dipyrido-[3,2-b:2',3'-e¦[1,4¦diazépines. Ces substances sont utiles pour le traitement de l'infection par le VIH. Voici des composés-types : 8-éthyle-1-méthyle-10-(4-pyrazolyle)imidazo[2,3':6,5¦dipyrido[3,2-b:2',3'-e¦[1,4¦diazépine; 8-c-propyle-1-méthyle-10-(4-pyrazolyle)imidazo-[2',3':6,5¦dipyrido[3,2-b:2',3'-e¦[1,4¦diazépine; 8-éthyle-12-méthyle-10-(4-pyrazolyle)imidazo[2',3':6,5¦dipyrido[[3,2-b:2',3'-e¦[1,4¦diazépine; 8-c-propyle-12-méthyle-10-(4-pyrazolyle)imidazo-[2',3':6,5¦dipyrido[3,2-b:2',3'-e¦[1,4¦diazépine.

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