C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/10 (2006.01) A61K 31/4245 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2583681
The present invention encompasses compounds of Formula I: as well as the pharmaceutically acceptable salts thereof. The compounds are S1P1/Edg1 receptor agonists and thus have immunosuppressive, anti-inflammatory and hemostatic activities by modulating leukocyte trafficking, sequestering lymphocytes in secondary lymphoid tissues, and enhancing vascular integrity. The invention is also directed to pharmaceutical compositions containing such compounds and methods of treatment or prevention.
L'invention concerne des composés représentés par la formule (I) ainsi que des sels de ceux-ci pharmaceutiquement acceptables. Ces composés sont des agonistes du récepteur S1P1/Edg1 et possèdent donc des activités immunosuppressives, anti-inflammatoires et hémostatiques par modulation du trafic des leucocytes, séquestration de ces lymphocytes dans des tissus lymphoïdes secondaires et amélioration de l'intégrité vasculaire. L'invention concerne également des compositions pharmaceutiques contenant ces composés et des méthodes de traitement ou de prévention.
Hale Jeffrey John
Yan Lin
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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