2-arylalkylthio -imidazoles, 2-arylalkenyl -thio -imidazoles...

Details 2-arylalkylthio -imidazoles, 2-arylalkenyl -thio -imidazoles... 2-arylalkylthio -imidazoles, 2-arylalkenyl -thio -imidazoles...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4439 (2006.01) A61K 31/497 (2006.01) A61K 31/506 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2344411

2-Arylaklylthioimidazoles, 2-arylalkenylthioimidazoles and 2-arylalkynylthioimidazoles as antiinflammatories and inhibitors of cytokine release The invention relates to 4-heteroaryl-5-phenylimidazole derivatives having 2-arylalkylthio, 2-arylalkenylthio and 2-arylalkynylthio substitution, of the general formula I: (See formula I) in which Ar is a phenyl radical, Het is a hetero aromatic radical, A is an alkylene chain, R1 is an alkylthio, alkylsulfinyl, alkylsulfonyl, sulfonamido or alkylcarbonyl group and R2 is an alkyl, hydroxyl, alkoxy, alkoxycarbonyl, sulfonamido, carboxyl, nitro or aminocarbonyl group or a halogen atom. n can be 1 or 2 and m is 0 to 2. The compounds according to the invention show antiinflammatory activity.

2-Arylalkylthio-imidazoles, 2-arylalcényl-thio-imidiazoles et 2-arylalcynyl-thio-imidazoles en tant que substances anti-inflammatoires et substances inhibant la libération des cytokines. La présente invention concerne des dérivés de 4-hétéroaryl-5-phényl-imidazole à substitution 2-arylalkylthio-, 2-arylalcénylthio et 2-arylalcynylthio de formule générale (I), dans laquelle Ar représente un reste phényle, Het représente un reste hétéroaromatique, A représente une chaîne alkylène, R<1> représente un groupe alkylthio, alkylsulfinyle, alkylsulfonyle, sulfonamido ou alkylcarbonyle et R<2> représente un groupe alkyle, hydroxy, alcoxy, alcoxycarbonyle, sulfonamido, carboxyle, nitro et aminocarbonyle ou un atome d'halogène. n peut valoir entre 1 et 2 et m vaut de 0 à 2. Les composés selon la présente invention ont une activité anti-inflammatoire.

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