C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4188 (2006.01) A61K 31/437 (2006.01) A61K 31/506 (2006.01) A61P 3/10 (2006.01) A61P 25/02 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) C07D 235/00 (2006.01) C07D 239/42 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2435177
The present invention relates to a new use of pyrimidine derivates of formula (I), as a free base or a pharmaceutically acceptable salt thereof in the manufacture of a medicament in the treatment and/or prophylaxis of conditiosn associated with glycogen synthase kinase-3. The present invention further relates to a method of treatment and/or propyhlaxis of conditions associated wiht glycogen synthase kinase-3, comprising administrating to a mammal, including man inneed of such prevention and/or prophylaxis a therapeutically effective amount of said pyrimidine derivatives, as well as a pharmaceutical formulation for said use. In addition , the present invention relates to new compounds suitable for the inhibition of glycogen synthase kinase-3.
La présente invention concerne une nouvelle utilisation de dérivés de pyrimidine de formule (I), sous la forme de base libre ou de sel pharmaceutiquement acceptable dans la fabrication d'un médicament pour le traitement et/ou la prophylaxie d'états associés à la kinase 3 de glycogène synthase. La présente invention concerne également une méthode de traitement et/ou de prophylaxie d'états associés à la kinase 3 de glycogène synthase, consistant à administrer à un mammifère, y compris l'homme, nécessitant une telle prévention et/ou une telle prophylaxie, une quantité efficace d'un point de vue thérapeutique desdits dérivés de pyrimidine, ainsi qu'une formulation pharmaceutique pour ladite utilisation. De plus, la présente invention concerne de nouveaux composés conçus pour inhiber la kinase 3 de glycogène synthase.
Berg Stefan
Bhat Ratan
Hellberg Sven
Astrazeneca Ab
Fetherstonhaugh & Co.
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