C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 261/20 (2006.01) A61K 31/192 (2006.01) A61K 31/41 (2006.01) A61K 31/423 (2006.01) A61K 31/427 (2006.01) A61K 31/4406 (2006.01) A61K 31/4439 (2006.01) A61P 3/00 (2006.01) C07C 59/90 (2006.01) C07D 213/55 (2006.01) C07D 263/32 (2006.01) C07D 263/58 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2437118
A class of 2-aryloxy-2-arylalkanoic acids comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR alpha and/or gamma mediated diseases, disorders and conditions.
L'invention concerne une classe d'acides 2-aryloxy-2-arylalcanoïques comprenant des composés qui sont des agonistes puissants de récepteur PPAR alpha et/ou gamma et qui permettent donc de traiter, de contrôler ou de prévenir le diabète non insulinodépendant (DNID), l'hyperglycémie, la dyslipidémie, l'hyperlipidémie, l'hypercholestérolémie, l'hypertriglycéridémie, l'athérosclérose, l'obésité, la resténose vasculaire, les troubles inflammatoires et autres maladies, troubles et états pathologiques induits par le récepteur PPAR alpha et/ou gamma.
Adams Alan D.
Berger Joel P.
Dropinski James F.
Elbrecht Alexander
Jones A. Brian
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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