C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/14 (2006.01) A61K 31/47 (2006.01) C07D 215/12 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 409/04 (2006.01)
Patent
CA 2392149
The invention concerns compounds of general formula (I) wherein: A represents a hydrogen atom, a hydroxy, a C1-C3 alkoxy, hydroxy C1-C3-alkyl, alkoxy C1-C3 alkyl, a thiol, C1-C6 alkylsulphanyl group or a halogen; B and D represent, independently of each other, a hydrogen atom, a C1-C6 alkyl, fluoro C1-C6 alkyl or perfluoro C1-C2 alkyl group, or B and D together form an oxo group; R1 represents a phenyl, a naphthyl or a heteroaryl comprising 4 or 5 carbon atoms; R2 and R3 represent, independently of each other, a hydrogen atom, a halogen, a C1-C6 alkyl group; R4 represents a hydrogen atom, a hydroxy or a halogen; and R5 and R6 represent, independently of each other, a hydrogen atom, a C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl, C3-C6 cycloalkenyl, fluoro-C1-C6 alkyl, perfluoro-C1-C2 alkyl group, or R5 and R6 together form a C2-C6 alkylene, C3-C6 alkenylene chain to produce with the nitrogen whereto they are bound a heterocycle, said heterocycle being optionally substituted with a C1-C4 alkyl group; and their salts. The invention has therapeutic uses.
Composés de formule générale (I), dans laquelle: A représente un atome d'hydrogène, un hydroxy, un groupe C¿1-3? alcoxy, hydroxy-C¿1-6? alkyle, C¿1-3? alcoxy-C¿1-3? alkyle, un thiol, C¿1-6? alkylsulfanyle ou un halogène; B et D représentent, indépendamment l'un de l'autre, un atome d'hydrogène, un groupe C¿1-6? alkyle, fluoro-C¿1-6? alkyle ou perfluoro-C¿1-2? alkyle, ou B et D forment ensemble un oxo; R¿1? représente un phényle, un naphtyle ou un hétéroaryle comprenant 4 ou 5 atomes de carbone; R¿2? et R¿3? représentent, indépendamment l'un de l'autre, un atome d'hydrogène, un halogène, un groupe C¿1-6? alkyle, R¿4? représente un atome d'hydrogène, un hydroxy ou un halogène, et R¿5? et R¿6? représentent, indépendamment l'un de l'autre, un atome d'hydrogène, un groupe C¿1-6? alkyle, C¿2-6? alkényle, C¿3-6? cycloalkyle, C¿3-6? cycloalkényle, fluoro-C¿1-6? alkyle, perfluoro-C¿1-2? alkyle ou R¿5? et R¿6?, forment ensemble une chaîne C¿2-6? alkylène, C¿3-6? alkénylène pour donner avec l'azote auquel ils sont rattachés un hétérocycle, cet hétérocycle étant éventuellement substitué par un groupe C¿1-4? alkyle; et leurs sels. Application en thérapeutique.
Bovy Philippe R.
Braun Alain
Philippo Christophe
Kirby Eades Gale Baker
Sanofi-Synthelabo
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