2-azabicyclo[2.2.1]heptane derivatives, preparation and...

Details 2-azabicyclo[2.2.1]heptane derivatives, preparation and... 2-azabicyclo[2.2.1]heptane derivatives, preparation and...

C - Chemistry, Metallurgy

07

D

C07D 471/08 (2006.01) C07C 271/24 (2006.01) C07D 209/02 (2006.01) C07D 209/52 (2006.01) C07D 317/44 (2006.01) C07D 491/18 (2006.01)

Patent

CA 2219456

Novel 1R or 1S 2-azabicyclo[2.2.1]heptane derivatives of general formula (I) or (I'), wherein R is a hydrogen atom or a radical of formula (II) or (II') respectively, where R1 is an alkyl radical containing 1-4 carbon atoms and Ar is an optionally substituted phenyl or alpha - or beta -naphthyl radical, and preparation and application thereof. The novel products of general formula (I) are particularly useful for preparing adenosine agonists.

Nouveaux dérivés du 2-azabicyclo[2.2.1]heptane 1R ou 1S de formule générale (I) ou (I'), leur préparation et leur application. Dans les formules générales (I) et (I'), R représente un atome d'hydrogène ou respectivement un radical de formule (II) ou (II') dans lesquelles R1 représente un radical alcoyle contenant 1 à 4 atomes de carbone et Ar représente un radical phényle ou .alpha.- ou .beta.-naphtyle éventuellement substitué. Les nouveaux produits de formule générale (I) sont particulièrement utiles pour préparer des agonistes d'adénosine.

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