C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/231, 260/273
C07D 453/06 (2006.01) A61K 31/445 (2006.01) C07D 211/82 (2006.01) C07D 491/18 (2006.01)
Patent
CA 1252101
ABSTRACT The invention relates to new 2-azabicyclco- [2.2.2] octane derivatives of the formula (I), (I) Image wherein A is hydrogen, alkoxycarbonyl having from one to 4 carbon atoms in the alkoxy moiety, phenylalkoxycarbonyl having from one to 4 carbon atoms in the alkoxy moiety, alkyl having from one to 6 carbon atoms, aralkyl containing from one to 4 carbon atoms in the alkyl moiety or sub- stituted acyl, R1 is hydrogen or alkyl having from one to 4 carbon atoms, z is hydrogen or halogen, X is hydrogen or halogen, Y is hydrogen, or X and Y together represent a C-C bond, W is alkoxycarbonyl having from one to 4 carbon atoms in alkoxy moiety, cyano, carboxamido or haloformyl, or - 60 - if X stands for halogen, X and Y together represent Image group. According to another aspect of the invention there is provided a process for the preparation of the above compounds, which are pharmaceutically active, in particular, possess valuable anticonvulsive, vasodilating or gastric acid secretion inhibiting properties. Pharmaceutical compositions containing compounds of the formula (I) are also within the scope of the invention.
457697
Acs Tibor
Bolcskei Hedvig
Ezer Elemer
Fekete Gyorgy
Hajos Gyorgy
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt
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