C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 221/22 (2006.01) A61K 31/435 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2522180
The subject invention relates to 2-azabicyclo[3.3.1 ]nonane derivatives, pharmaceutical compositions comprising such derivatives and methods of using such derivatives to treat disease states, disorders and conditions mediated by opioid receptors. The subject invention also particularly relates to using such derivatives to treat certain disorders and conditions, for example irritable bowel syndrome, drug addiction, including alcohol addiction, depression, anxiety, schizophrenia and eating disorders, among others, as are more fully described herein. Formula (I):
L'invention se rapporte à des dérivés de 2-azabicyclo[3.3.1]nonane, à des compositions pharmaceutiques les contenant et à des procédés d'utilisation de ces dérivés pour traiter des états pathologiques, des troubles et des états induits par des récepteurs opioïdes. L'invention se rapporte plus particulièrement à l'utilisation de ces dérivés pour traiter certains troubles et certains états tels que, entre autres, le côlon irritable, la toxicomanie, y compris l'alcoolisme, la dépression, l'anxiété, la schizophrénie et les troubles de l'alimentation, tels que décrits plus amplement dans la description.
Coe Jotham Wadsworth
Mchardy Stanton Furst
Pfizer Products Inc.
Smart & Biggar
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