2-azabicycloalkane-3-carboxylic acid derivatives, processes...

Details 2-azabicycloalkane-3-carboxylic acid derivatives, processes... 2-azabicycloalkane-3-carboxylic acid derivatives, processes...

C - Chemistry, Metallurgy

07

D

260/207.7

C07D 209/42 (2006.01) C07D 209/08 (2006.01) C07D 209/34 (2006.01) C07D 209/52 (2006.01) C07D 215/227 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341296

Disclosed are cis, exo- and trans-compounds of the formula I (see formula I) in which n denotes 0, 1 or 2, R1 denotes hydrogen, (C1-C6)- alkyl which can optionally be substituted by amino, (C1-C4)- acyl- or bezoylamino, (C2-C6)-alkenyl, (C5-C9)-cycloalkyl, (C5-C9)-cycloalkenyl, (C5-C7)-cycloalkyl-(C1-C4)-alkyl, aryl or partially hydrogenated aryl, which can, in each case, be substituted by (C1-C2)-alkyl, (C1-C2)-alkoxy or halogen, aryl-(C1-C4)-alkyl, /which can be substituted as defined previously in the aryl radical/, a monocyclic or bicyclic sulfur or nitrogen and/or nitrogen heterocyclic radical, or a side chain of naturally occurring aminoacid, R2 denotes hydrogen, (C1-C6)-alkyl, (C2-C6)alkenyl or aryl-(C1-C4)- alkyl Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen, X denotes (C1-C6)-alkyl, (C2-C6)-alkenyl, (C5-C9)-cycloalkyl or aryl which can be mono-, di- or tri- substituted by (C1-C4)-alkyl, (C1-C4)-alkoxy, hydroxyl, halogen, nitro, amino, (C1-C4)- alkylamino, di-(C1-C4-alkylamino or methylenedioxy, or indol-3-yl, or physiologically acceptable salts thereof, a process ofr the preparation thereof, agents containing them, their use as a medicine and intermediates for the prepara- tion thereof.

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