C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/111, 167/188
C07D 499/00 (2006.01) A61K 31/43 (2006.01) C07D 207/12 (2006.01) C07D 207/273 (2006.01) C07D 207/277 (2006.01) C07D 207/416 (2006.01) C07D 211/54 (2006.01) C07D 211/76 (2006.01) C07D 263/20 (2006.01) C07D 265/06 (2006.01) C07D 265/10 (2006.01) C07D 277/14 (2006.01) C07D 499/88 (2006.01) C07F 7/18 (2006.01)
Patent
CA 1263644
D.P.C.(PhRe) 6739/A 2-AZACYCLOALKYLTHIOPENEM DERIVATIVES Abstract Certain 2-azacycloalkylthio-2-penem-3-carboxylic acid compounds are useful as antibacterials for treating mammals and have the formula Image ---I or a pharmaceutically acceptable salt thereof, wherein: R is Image 72222-30 A is alkylene having 2-4 carbon atoms, alkylene having 2-4 carbon atoms wherein a carbon atom has an oxo substituent or alkylene having 2-4 carbon atoms wherein a methylene is replaced by oxygen or sulfur; B is carbonyl or methylene; R1 is hydrogen or forms an ester group which is hydrol- yzed in vivo; R2 is hydrogen, formyl or alkyl has 1-4 carbon atoms; alk is alkylene having 1-4 carbon atoms; and n is zero or one; with the proviso that R2 is formyl when s is methylene and A is alkylene having 2-4 carbon atoms, alkylene having 2-4 carbon atoms wherein a carbon atom has an oxo substituent and said carbon atom is not adjacent to the nitrogen atom of R or alkylene having 2-4 carbon atoms wherein a methylene is replaced by oxygen or sulfur.
465259
Hamanaka Ernest S.
Limited Pfizer
Smart & Biggar
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