2-azapurine compounds and their use

Details 2-azapurine compounds and their use 2-azapurine compounds and their use

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C07H 19/04 (2006.01) C07H 19/10 (2006.01) C07H 19/20 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2384407

Within oligonucleotides 2-azapurine and especially 2-azaadenine bases form specifically base pairs with guanine. This base pair is of analogous stability as an adenine-thymine but less stable than a guanine-cytosine base pair. Therefore, the incorporation of 2-azaadenine residues into oligonucleotides instead of cytosine leads specifically to hybridization complexes with nucleic acids with homogenous stability. This is useful for the adaptation of the stabilities of different oligonucleotide sequences in all kinds of hybridization techniques, for example in oligomer chip technology.

Dans les oligonucléotides, les bases 2-azapurine et en particulier 2-aza-adénine forment spécifiquement des paires de bases avec guanine. Cette paire de bases a une stabilité analogue à celle de la paire adénine-thymine mais inférieure à celle d'une paire de bases guanine-cytosine. Par conséquent, l'incorporation de résidus de 2-aza-adénine dans des oligonucléotides au lieu de cytosine engendre spécifiquement des complexes d'hybridation avec des acides nucléiques à stabilité homogène. Cette incorporation permet ainsi d'adapter les stabilités de différentes séquences d'oligonucléotides dans tous les types de techniques d'hybridation, par exemple dans la technologie des puces à oligomères.

Affiliated with

Also associated with

Rating

2-azapurine compounds and their use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-azapurine compounds and their use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-azapurine compounds and their use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1437124