2-azaspiro[4.(3 n)]alkane-3-carboxylic acid derivatives, a...

Details 2-azaspiro[4.(3 n)]alkane-3-carboxylic acid derivatives, a... 2-azaspiro[4.(3 n)]alkane-3-carboxylic acid derivatives, a...

C - Chemistry, Metallurgy

07

D

260/325.1

C07D 209/54 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1197857

-1- Abstract of the disclosure: The invention relates to compounds of the formula Image (I) in which n denotes 1, 2, 3 or 4, R is alkyl, alkenyl, cyclo- alkyl, aryl, optionally mono-, di- oder trisubstituted by alkyl, alkoxy, hydroxy, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or indol-3-yl, R1 denotes an optionally protected radical of a naturally occurring amino acid HOOC-CH(NH2)-R1, R2 denotes hydrogen, alkyl or option- ally nitro-substituted aralkyl, R3 denotes hydrogen, alkyl or cycloalkyl or optionally nitro-substituted aralkyl and X denotes 2 hydrogen atoms or 1 oxygen atom, their physiolo- gically tolerated salts with acids and, if R2 and/or R3 denote hydrogen, with bases, a process for their preparation, agents containing these derivatives and their use as medicaments.

424488

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