2-(benzimidazol-1-yl)-n-(4-phenylthiazol-2-yl) acetamide...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 417/12 (2006.01) A61K 31/427 (2006.01)

Patent

CA 2627260

The invention relates to 2-(benzimidazol-1-yl)-N-(4-phenylthiazol-2-yl) acetamide derivatives having the general Formula (I) wherein R1 is H, (C1- 4)alkyl, (C1-4)alkyloxy or halogen; R2 represents 1-3 substituents selected from H, (C1-4)alkyl (optionally substituted with 1 or more halogens), (C1- 4)alkyloxy (optionally substituted with 1 or more halogens), halogen, CF3 or cyano; or a pharmaceutically acceptable salt thereof; to pharmaceutical compositions comprising the same and to the use of said 2-(benzimidazol-1-yl)- N-(4-phenylthiazol-2-yl) acetamide derivatives in the treatment of TRPV1 mediated disorders.

La présente invention concerne des dérivés acétamidiques de 2-(benzimidazol-1-yl)-N-(4-phénylthiazol-2-yl) représentés par la formule générale (I) ou l'un de ses sels pharmaceutiquement admis. Dans cette formule, R1 est H, (C1-4)alkyle, (C1-4)alkyloxy ou halogène. R2 représente des 1-3 substituants choisis parmi les H, (C1-4)alkyle (éventuellement substitué par au moins 1 halogène), (C1-4)alkyloxy (éventuellement substitué par au moins 1 halogène), halogène, CF3 ou cyano. L'invention concerne également des compositions pharmaceutiques à base de ces dérivés et leur utilisation pour le traitement de troubles en lien avec TRPV1.

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