2-benzothiazolyl oxamic acid and esters

Details 2-benzothiazolyl oxamic acid and esters 2-benzothiazolyl oxamic acid and esters

C - Chemistry, Metallurgy

07

D

260/309.3

C07D 277/82 (2006.01)

Patent

CA 1118781

3499 ABSTRACT OF THE DISCLOSURE Novel compounds of the formula Image wherein X and Y are the same or different and are hydrogen, fluoro, chloro, bromo, alkyl of one to six carbon atoms, inclusive, alkoxy of one to six carbon atoms, inclusive, nitro, cyano, amino, trifluoromethyl, Image wherein R1 is alkyl of one to six carbon atoms, inclusive, Image wherein R2 and R3 are the same or different and are hydrogen or alkyl of one to three car- bon atans inclusive, or CO2Q where Q is alkyl of one to six carbon atoms, inclusive, hydrogen or a physiologic- ally acceptable metal or amine cation; and R is hydrogen, alkyl of one to eight carbon atoms, inclusive, Image phenyl wherein m is 0, 1 or 2 or (CH2)nNR4R5 wherein n is 1 or 2, and R4 and R5 are the same or different and are alkyl of one to three car- bon atoms, inclusive, and a physiologically acceptable metal or amine cation; and physiologically acceptable acid addition salts thereof are formulated into pharma- ceutical compositions suitable for oral, parenteral or inhalation administration which are used as prophylactic inhibitors of allergic manifestations in sensitized mammals. -1-

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