2-benzothiazolyl urea derivatives and their use as protein...

Details 2-benzothiazolyl urea derivatives and their use as protein... 2-benzothiazolyl urea derivatives and their use as protein...

C - Chemistry, Metallurgy

07

D

C07D 277/82 (2006.01) A61K 31/428 (2006.01) A61K 31/435 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 451/02 (2006.01) C07D 451/04 (2006.01) C07D 451/14 (2006.01) C07D 453/02 (2006.01) C07D 487/08 (2006.01) C07D 513/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2398754

The present invention is directed to a compound of formula (I), racemic- diastereomeric mixtures thereof, optical isomers thereof, prodrugs thereof, isotopes thereof or pharmaceutically-acceptable salts of said compound, isomers, prodrugs and isotopes, wherein the variable are defined herein. The compounds of this invention are useful as inhibitors of serine/threonine and tyrosine kinases. In particular, compounds of this invention are useful as inhibitors of tyrosine kinases that are important in hyperproliferative diseases, especially in cancer and in the process of angiogenesis.

L'invention concerne un composé représenté par la formule (I), des mélanges racémiques-diastéréomériques, des isomères optiques, des promédicaments, des isotopes ou des sels pharmaceutiquement acceptables de ce composé, de ces isomères, de ces promédicaments et de ces isotopes; les variables étant définies dans cette invention. Les composés décrits dans cette invention sont utilisés comme inhibiteurs de sérine/thréonine et de tyrosine kinases. Plus particulièrement, les composés susmentionnés sont utilisés comme inhibiteurs des tyrosine kinases qui jouent un rôle prépondérant dans les maladies hyperproliférantes, spécialement le cancer, et dans les processus d'angiogénèse.

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