C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/58 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07D 333/56 (2006.01) C07D 333/72 (2006.01) C07F 7/08 (2006.01)
Patent
CA 2214134
The present invention provides derivatives of 2-phenylmethyl-3-[4-(2- aminoethoxy)phenyl]-benzo[b]thiophene. The present invention further provides pharmaceutical compositions containing these derivatives and the use of such compounds alone, or in combination with estrogen or progestin, for alleviating the symptoms of post-menopausal syndrome, particularly osteoporosis, cardiovascular related pathological conditions, and estrogen-dependent cancer. These compounds are also useful for inhibiting uterine fibroid disease and endometriosis in women and aortal smooth muscle cell proliferation, particularly restenosis, in humans.
L'invention concerne des dérivés de 2-phénylméthyle-3-(4-(2-aminoéthoxy-phényle)-benzo(b)thiophène. L'invention traite également de compositions pharmaceutiques contenant ces dérivés et l'utilisation de tels composés seuls, ou en association avec des oestrogènes ou de la progestine pour traiter des symptômes tels que les syndromes des femmes ménopausées, en particulier l'ostéoporose, des troubles pathologiques liés aux problèmes cardiovasculaires, et le cancer oestrogéno-dépendant. Ces composés permettent également d'inhiber des maladies telles que les fibromes utérins et l'endométriose chez la femme, et la prolifération des cellules des muscles lisses aortiques, en particulier, la resténose chez l'humain.
Cullinan George Joseph
Sales James Joseph
Eli Lilly And Company
Gowling Lafleur Henderson Llp
LandOfFree
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