C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 167/273
C07D 295/08 (2006.01) C07C 227/08 (2006.01) C07C 227/16 (2006.01) C07D 295/084 (2006.01)
Patent
CA 1242728
2-Benzyl-3-phenoxy-propylamines Abstract of the disclosure The invention concerns antidepressive compounds of the formula I Image (I) wherein R1 and R2 independently of the other represent hydrogen or lower alkyl; or R1 and R2 together with the adjacent nitrogen atom represent piperidino or pyrrolidino or a five- or six-membered saturated heterocyclic ring containing NH, N-lower alkyl, O or S; R3 represents hydrogen, lower alkyl, lower alkoxy, halogen or tri- fluoromethyl; Ar represents phenyl or phenyl substituted by one to three substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkenyloxy, lower alkynyloxy, lower alkylmercapto, lower alkylsulfinyl, lower alkylsulfonyl, halogen and trifluoromethyl, or by one lower alkylenedioxy; and X represents O, S or N-lower alkyl, and n represents an integer 1, 2 or 3; N-oxides thereof; acid addition salts thereof; and N-lower alkyl or N-benzyl quaternary salts thereof; except the compound of formula I wherein R1 and R2 represent ethyl, R3 represents hydrogen, Ar represents phenyl; X represents 0, and n is 3, and acid addition salts thereof. They are prepared, for example, by reducing a compound structurally analogous to a compound of formula I, wherein an oxo group is present on one carbon atom adjacent to the amino nitrogen.
435963
Fetherstonhaugh & Co.
Novartis Ag
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