C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/323
C07D 207/08 (2006.01) C07D 207/14 (2006.01) C07D 207/20 (2006.01) C07D 207/22 (2006.01) C07D 207/24 (2006.01)
Patent
CA 1104572
ABSTRACT OF THE DISCLOSURE Substituted 2-benzylpyrrolidines of the general formula Image wherein R1 denotes a hydrogen atom, a straight-chain or branched aliphatic or alicyclic hydrocarbon radical, a cyclo- alkylalkyl group or an aralkyl group, R2 denotes a halogen atom, an alkyl group, a hydroxyl group, an alkoxy group, an acyloxy group, an amino group which may be substituted, a nitro group, a phenyl group which may be substituted, R3, R4 and R5 are the same or different and denote a hydrogen atom, a halogen atom, an alkyl group, a hydroxyl group, an alkoxy group, an acyloxy group, an optionally substituted amino group, a nitro group, an optionally substituted phenyl group, and their quaternary alkyl-pyrrolidinium compounds and their acid addition salts are pharmacologically active compounds. They display actions on the central nervous system, the blood pressure and the pain sensation of warm-blooded animals. Their preparation is effected according to various processes, e.g. through reduction of corresponding 2-benzylpyrrolidines or functionalisation of corresponding 2-benzylpyrrolidines or reduction of N-acyl-2-benzyl-pylrolidines.
283611
Eistetter Klaus
Menge Heinz G.
Schaefer Hartmann
Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankte
Fetherstonhaugh & Co.
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