C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 71/00 (2006.01) A61K 31/58 (2006.01) C07J 51/00 (2006.01)
Patent
CA 2096020
The present invention is directed to 2.beta.,19-(methyleneamino)androst-4-ene- 3,17-dione and the corresponding 17.beta.-ol which are useful as aromatase inhibitors. The compounds are prepared by the cyclization of an appropriate 19-N-protected-[(2-methox- yethoxy)methylamino] steroid using titanium tetrachloride followed by, if desired, selective reduction of the 17-ketone.
Burkhart Joseph P.
Johnston J. O'neal
Peet Norton P.
Merrell Dow Pharmaceuticals Inc.
Merrell Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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