2.beta.-substituted thiomethylpenicillin derivatives and...

C - Chemistry – Metallurgy – 07 – D

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260/111

C07D 499/00 (2006.01)

Patent

CA 1281319

ABSTRACT OF THE DISCLOSURE: Disclosed is a penicillin derivative of the formula: Image wherein n is an integer of 0, 1 or 2; Y is a cyano group, a lower acyl group, a mono- or di-lower alkylthiocarbamoyl group, Image , Image or Image wherein R1 is a hydrogen atom, a lower alkyl group, a phenyl group, a group -(CH2)m-OR2 or -(CH2)mCOOR2 (m is an integer of 1 to 6 and R2 is a hydrogen atom or a penicillin carboxyl ester-forming group which is commonly used for penicillin derivatives) or a phenyl group substituted by at least one member selected from the class consisting of lower alkyl group, halogen atom and lower alkoxy group; and R is a hydrogen atom or a penicillin carboxyl ester-forming group, or a salt thereof. They are useful as .beta.-lactamase inhibitors.

530613

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