C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) A61K 31/415 (2006.01) A61K 31/47 (2006.01) A61K 31/535 (2006.01) A61K 31/675 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01) C07D 487/04 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01) C07F 9/6558 (2006.01)
Patent
CA 2066690
-48- Summary The invention concerns new compounds of the general formula I Image (I), in which R1 signifies a hydrogen atom, a C1-C6-alkyl, C2-C6-alkenyl or a C3-C7-cycloalkyl group, R2 represent a C1-C6-alkyl, C2-C6-alkenyl or cyano group, a carbonyl group substituted by a hydroxyl, C1-C6-alkyl, C1-C6- alkoxy, amino, C1-C6-alkylamino, di-C1-C6-alkylamino or hydrazino group or R1 and R2 together represent a C2-C6-alkylidene or C3-C6-cycloalkylidene group or R1 and R2, together with the carbon atom to which they are attached, form a C3-C7-spirocycle, n can be equal to 0 ot 1, R3 signifies a hydrogen atom, a C1-C8-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, benzyl, carboxy-C1-C6-alkyl, C1-C6-alkyloxycarbonyl-C1-C6- alkyl or di-C1-C6-alkyloxophosphinyl-C1-C6-alkyl group and the radicals R4 - R6 possess the meanings defined in the description. The compounds of the general formula I serve for the preparation of medicaments. In small concentrations, they inhibit not only the erythrocyte aggregation but also the thrombocyte aggregation. On the basis of these properties, these substances are suitable for the -49- treatment of diseases in which, in the pathogenesis, the erythrocyte and thrombocyte aggregation play an important part.
Boehm Erwin
von Der Saal Wolfgang
Zilch Harald
Boehringer Mannheim Gmbh
Swabey Ogilvy Renault
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