2-cyanopyrrolopyrimidines and pharmaceutical uses thereof

Details 2-cyanopyrrolopyrimidines and pharmaceutical uses thereof 2-cyanopyrrolopyrimidines and pharmaceutical uses thereof

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01) C07D 471/10 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2514287

The invention relates to pyrrolo pyrimidines of formula (I), wherein Y represents -(CH2)t-O- or -(CH2)r-S-, p is 1 or 2, r is 1, 2 or 3, t is 1, 2 or 3, or Y is -(CH2)j- or -CH=CH-, j is 1 or 2; p is 1 or 2, or Y is -(CH2)f-, f is 1 or 2, p is 1, and the further radicals and symbols have the meaning as defined herein; their preparation, their use as pharmaceuticals, pharmaceutical compositions containing them, the use of such a compound for the manufacture of a pharmaceutical preparation for the treatment of neuropathic pain and to a method for the treatment of such a disease in animals, especially in humans.

L'invention concerne des pyrrolo pyrimidines de formule (I), dans laquelle Y représente -(CH¿2?)¿t?-O- ou -(CH¿2?)¿r?-S-, p prend la valeur de 1 ou 2, r prend la valeur de 1, 2 ou 3, t prend la valeur de 1, 2 ou 3, ou Y désigne -(CH¿2?)¿j?- ou -CH=CH-, j prend la valeur de 1 ou 2; p prend la valeur de 1 ou 2, ou Y représente -(CH¿2?)¿f?-, f prend la valeur de 1 ou 2, p prend la valeur de 1, et les autres radicaux et symboles ont la signification définie dans la description; la préparation de celles-ci, l'utilisation de celles-ci comme agents pharmaceutiques, des compositions pharmaceutiques renfermant celles-ci, l'utilisation d'un tel composé dans la fabrication d'une préparation pharmaceutique destinée au traitement de douleurs neuropathiques et une méthode de traitement d'une telle maladie chez des animaux, notamment les êtres humains.

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