C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 249/16 (2006.01) A61K 31/415 (2006.01) C07D 235/08 (2006.01) C07D 235/10 (2006.01) C07D 235/12 (2006.01) C07D 235/14 (2006.01) C07D 235/16 (2006.01) C07D 235/30 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2389234
Novel 4-substituted cyclohexanes substituted in the 1-position with 2- benzimidazoles, 2-imidazopyridines, or 4-imidazoles either directly or through a C1-C4alkyl, cycloalkyl, hydroxyalkyl, alkoxy or aminoalkyl chain are effective as NMDA NR2B antagonists useful for relieving pain.
L'invention concerne de nouveaux cyclohexanes 4-substitués qui sont substitués en position 1 par des 2-benzimidazoles, des 2-imidazopyridines ou des 4-imidazoles, soit directement, soit à l'aide d'un alkyle C¿1?-C¿4?, d'un cycloalkyle, d'un hydroxyalkyle, d'un alcoxy ou d'une chaîne aminoalkyle. Ces nouveaux cyclohexanes sont efficaces en tant qu'antagonistes NMDA NR2B utiles pour atténuer la douleur.
Claremon David A.
Mccauley John A.
Munson Peter M.
Thompson Wayne
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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