2-cyclopenten-1-one as an inducer of hsp70

Details 2-cyclopenten-1-one as an inducer of hsp70 2-cyclopenten-1-one as an inducer of hsp70

A - Human Necessities

61

K

A61K 31/12 (2006.01) A61K 31/122 (2006.01)

Patent

CA 2258675

The invention relates to 2-cyclopenten-1-one as an inducer of the heat shock protein HSP70 by activating the heat shock transcription factor HSF, and selectively inducing the transcription and translation of HSP70 in human cells. In particular, since a cytoprotective role of HSP70 during viral infection was previously shown, the invention refers to 2-cyclopenten-1-one and its pharmaceutically acceptable derivatives as inducers of HSP70 with antiviral activity. Treatment with 2- cyclopenten-1-one and its pharmaceutically acceptable derivatives causes a dose-dependent reduction of infectious virus yield during infection with vesicular stomatitis virus. The block of virus replication is due to inhibition of viral protein synthesis, associated with HSP70 synthesis.

L'invention concerne la 2-cyclopentène-1-one utilisée comme inducteur de la protéine de choc thermique HSP70, par activation du facteur du choc thermique HSF, puis induction sélective de la transcription et de la translation de l'HSP70 dans les cellules humaines. En particulier, comme le rôle cytoprotecteur de l'HSP70 lors d'une infection virale avait déjà été démontré, l'invention concerne la 2-cyclopentène-1-one et ses dérivés pharmaceutiquement acceptables utilisés comme inducteurs de l'HSP70 présentant une activité antivirale. Le traitement par la 2-cyclopentène-1-one et ses dérivés pharmaceutiquement acceptables entraîne une réduction, proportionnelle à la dose administrée, de la production de virus infectieux durant une infection par le virus de la stomatite vésiculeuse. Le blocage de la réplication des virus est dû à l'inhibition de la synthèse de la protéine virale, associée à la synthèse de l'HSP70.

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