2-debenzoyl-2-acyl taxol derivatives and methods for making...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 305/14 (2006.01) A61K 31/335 (2006.01) A61K 31/38 (2006.01) A61K 31/665 (2006.01) A61K 31/695 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01) C07F 9/655 (2006.01)

Patent

CA 2118867

ABSTRACT The present invention relates to 2-debenzoyl-2-acyl taxol derivatives, analogues thereof and methods for making same. Compounds of the present invention include compounds having the general formula: Image wherein R1 is an alkyl or substituted alkyl; R2 is selected from the group consisting of H and C(O)Ra; R3 is selected from the group consisting of H, protecting groups, Rb, and C(O)Rb; R4 is selected from the group consisting of H and C(O)Rc, and wherein Ra, Rb, and Rc are independently selected from the group consisting of alkyls, substituted alkyls, alkenyls, alkynyls, aryls, and substituted aryls; provided that Ra is other than phenyl and 3-hydroxyphenyl.

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