2'-deoxy-2'-methylidenecytidine dihydrate, methods for its...

Details 2'-deoxy-2'-methylidenecytidine dihydrate, methods for its... 2'-deoxy-2'-methylidenecytidine dihydrate, methods for its...

C - Chemistry, Metallurgy

07

H

167/202, 260/229

C07H 19/073 (2006.01) A61K 31/70 (2006.01) A61K 47/12 (2006.01) A61K 47/26 (2006.01) C07H 19/06 (2006.01)

Patent

CA 2036507

Disclosed are novel 2'-deoxy-2'-methylidenecytidine (DMDC) dihydrate, its methods for production, and compositions with improved solubility containing same. The dihydrate is more stable and less hygroscopic than its corresponding acid addition salt, such as hydrochloride,and is useful as an antitumor or antiviral agent. Also disclosed is a composition of DMDC dihydrate further stabilized by a saccharide.

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