2-deoxy-2'-n-acyl and alkyl fortimicins a and b

Details 2-deoxy-2'-n-acyl and alkyl fortimicins a and b 2-deoxy-2'-n-acyl and alkyl fortimicins a and b

C - Chemistry, Metallurgy

07

H

260/300, 260/360

C07H 15/22 (2006.01) C07H 15/224 (2006.01)

Patent

CA 1126741

Abstract 2-Deoxy-2'-N-acyl and alkyl fortimicin B and derivatives, 4,2'-N,N'-diacyl and dialkyl fortimicin B derivatives, 4-N-acyl-2'-N-alkyl- and 4-N-alkyl-2'-N-acyl fortimicin B derivatives represented by the formula Image wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminolower- alkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N- diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N- loweralkylaminohydroxyloweralkyl or N,N-diloweralkylamino- hydroxyloweralkyl; and R1 is acyl, aminoacyl, N-monolower- alkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-sub- stituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkylaminoloweralkyl, hydroxyloweralkyl, N-loweralkyl- aminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxy- loweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-dilower- alkylaminohydroxyloweralkyl, hydrogen; and the pharmaceutically acceptable salts therefor, pharmaceutical compositions con- taining the compounds and methods of making and using the compounds. The compounds of this invention are useful as antibiotics.

314077

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