2'-deoxy-3',5'-di-o-alkylcarbonyl-5-fluorouridine...

Details 2'-deoxy-3',5'-di-o-alkylcarbonyl-5-fluorouridine... 2'-deoxy-3',5'-di-o-alkylcarbonyl-5-fluorouridine...

C - Chemistry, Metallurgy

07

H

260/229.3

C07H 19/06 (2006.01)

Patent

CA 1173436

2'-DEOXY-3',5'DI-O-ALKYLCARBONYI,-5- FLUOROURIDINE DERIVATIVES, A PROCESS FOR THE PREPARATION OF THE DERIVATIVES AND ANTI-TUMOR AGENTS CONTAINING THE DERIVATIVES ABSTRACT OF THE DISCLOSURE 2'-Deoxy-3',5'-di-O-alkylcarbonyl-5-fluorouridine derivatives possessing strong anti-tumor activity with weak toxicity and represented by the qeneral formula: Image wherein R stands for an alkyl group, an alkoxy group or a halogen atom, m for zero or an integer of 1-3, and n for an integer of 1, 2 or 5-14, with the proviso that when m is 2 or 3, R's may be the same or different and that when m is 2 and the adjacent two R's are alkoxy groups, the two alkyl moieties of the alkoxy groups may be combined to form together with the two adjacent oxa bridging members an alkylenedioxy group as a whole. These derivatives are prepared by acylating a 2'-deoxy-3',5'-di-O-alkylcarbonyl- 5-fluorouridine with corresponding benzoyl halides and are useful as active ingredients for anti-tumor agents, expecially for oral administration.

370765

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