2'-deoxy-5- substituted uridine derivatives, processes for...

Details 2'-deoxy-5- substituted uridine derivatives, processes for... 2'-deoxy-5- substituted uridine derivatives, processes for...

C - Chemistry, Metallurgy

07

H

260/229.3

C07H 19/073 (2006.01) C07H 19/06 (2006.01)

Patent

CA 1227794

ABSTRACT OF THE DISCLOSURE Novel 2'-deoxy-5-substituted uridine derivative repre- sented by the general formula, Image wherein R1 is a hydrogen atom, a benzoyl group or a tetrahydro- furanyl group; R2 is a fluorine atom or a trifluoromethyl group; and any one of R3 and R4 is a hydrogen atom and the other one is an alkyl group having 2 to 10 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a benzyl group which is unsubstituted or is substituted by a substituent selected from the group consisting of a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms and a nitro group, or an alkyl group having 1 to 3 carbon atoms having one or two phenyl groups as the substituents. The novel 2'-deoxy-5- substituted uridine derivative possesses excellent antitumor activity with less toxicity, thus it is useful as antitumor agent.

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