2"-deoxy hygromycin derivatives

Details 2"-deoxy hygromycin derivatives 2"-deoxy hygromycin derivatives

C - Chemistry, Metallurgy

07

H

C07H 15/26 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2331261

This invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1 and R2 are as defined herein. The compounds of formula (1) are antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula (1) and to methods of treating bacterial and protozoal infections by administering the compounds of formula (1).

L'invention concerne des composés de formule (1) et des sels, des promédicaments et des solvates de ceux-ci, acceptables au plan pharmaceutique, R<1> et R<2> étant définis dans la description. Les composés de formule (1) sont des agents antibactériens et antiprotozoaires pouvant être utilisés pour le traitement de diverses infections bactériennes et protozoaires et de troubles associés à ces infections. L'invention porte aussi sur des compositions pharmaceutiques contenant lesdits composés de formule (1) et sur des méthodes de traitement d'infections bactériennes et protozoaires par l'administration des composés de formule (1).

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