2'-deoxyguanosine hybrid compound containing pyrrole amide...

Details 2'-deoxyguanosine hybrid compound containing pyrrole amide... 2'-deoxyguanosine hybrid compound containing pyrrole amide...

C - Chemistry, Metallurgy

07

H

C07H 19/173 (2006.01) C07C 271/20 (2006.01) C07D 207/34 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2621104

It is intended to provide an MGB polyamide hybrid compound which has a function of recognizing a base sequence useful in gene therapy, is efficacious in synthesizing an oligomer and has a high stability. An MGB polyamide hybrid compound represented by the following formula (38) which is characterized by being a pyrrole amide tetramer prepared by introducing a 1-methylpyrrole-2- carbonyl group as a substitute for the N-terminal formyl group in the existing case.

La présente invention concerne un composé hybride polyamide MGB dont l'une des fonctions est de reconnaître une séquence de base pouvant être employée en thérapie génique. Ledit composé peut être efficacement employé dans la synthèse d'un oligomère et présente une stabilité importante. La présente invention concerne notamment un composé hybride polyamide MGB de formule (38) suivante caractérisé en ce qu'il s'agit d'un tétramère de pyrrole-amide obtenu par l'introduction d'un groupement 1-méthylpyrrole-2-carbonyle à la place du groupement formyle N-terminal dans le composé existant.

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