2-descarboxy-2 (tetrazol-5-yl)-11-desoxy-15-substituted...

Details 2-descarboxy-2 (tetrazol-5-yl)-11-desoxy-15-substituted... 2-descarboxy-2 (tetrazol-5-yl)-11-desoxy-15-substituted...

C - Chemistry, Metallurgy

07

D

260/235.01

C07D 257/06 (2006.01) C07C 405/00 (2006.01) C07D 257/04 (2006.01) C07D 307/935 (2006.01) C07F 9/40 (2006.01) C07F 9/6524 (2006.01)

Patent

CA 1059122

ABSTRACT OF THE DISCLOSURE The 2-descarboxy-2-(tetrazol-5-yl)-11-desoxy-15-sub- stituted-.omega.-pentanorprostaglandins and the magnesium salts thereof and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins but exhibit a greater tissue specificity of action. The process of preparing these compounds by hydrolysis of blocking groups on the 15-position is described.

241440

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