2-epi-fortimicin a and derivatives

Details 2-epi-fortimicin a and derivatives 2-epi-fortimicin a and derivatives

C - Chemistry, Metallurgy

07

H

260/360.3, 260/3

C07H 15/22 (2006.01) C07H 15/224 (2006.01)

Patent

CA 1149814

Abstract What is described is 2-epi-fortimicin A, 2-epi- fortimicin B or a 2-epi-fortimicin B derivative represented by the formula: Image wherein R1 is hydrogen or loweralkyl; R2 is hydrogen or hydroxy; R3 is methyl or hydrogen; and R4 is selected from the group consisting or hydrogen, loweralkyl, aminolower- alkyl, diaminolowerealkyl, N-loweralkylaminoalkyl, N,N-di- loweralkylaminoloweralkyl, hydroxyloweralkyl, aminohydroxy- loweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-dilower- alkylaminohydroxyloweralkyl, acyl of the formula Image wherein R5 is loweralkyl, aminoacyl, diaminoacyl, hydroxy- acyl, N-loweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl or an amino acid residue other than those defined above and the pharmaceutically acceptable salts thereof useful in the treatment of infections.

348565

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