2-ethyl and 2-ethylidene-19-nor-vitamin d compounds

Details 2-ethyl and 2-ethylidene-19-nor-vitamin d compounds 2-ethyl and 2-ethylidene-19-nor-vitamin d compounds

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/593 (2006.01)

Patent

CA 2410880

Biologically active 19-nor vitamin D analogs substituted at C-2 in the A-ring with an ethylidene or an ethyl group. These compounds have preferential activity on mobilizing calcium from bone and either high or normal intestinal calcium transport activity which allows their in vivo administration for the treatment of metabolic bone diseases where bone loss is a major concern. These compounds are also characterized by high cell differentiation activity.

Analogues biologiquement actifs de 19-nor-vitamine D substitués au niveau de C-2 dans le noyau A par un groupe éthylidène ou éthyle. Ces composés exercent une activité préférentielle de mobilisation du calcium osseux et une activité de transport du calcium intestinal élevée ou normale, ce qui permet d'effectuer leur administration in vivo afin de traiter des maladies osseuses métaboliques dans lesquelles la perte osseuse joue un rôle préoccupant. Ces composés sont également caractérisés par une activité élevée de différenciation cellulaire.

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