2-fluoro-2-alkyl alkanoamides with anticonvulsant activity

Details 2-fluoro-2-alkyl alkanoamides with anticonvulsant activity 2-fluoro-2-alkyl alkanoamides with anticonvulsant activity

C - Chemistry, Metallurgy

07

C

C07C 233/03 (2006.01) A61K 31/16 (2006.01) C07C 233/05 (2006.01)

Patent

CA 2335598

Alpha-fluorinated alkanoamides of formula (I), and pharmaceutical compositions containing them, are provided. The compounds and compositions are useful for the treatment and prevention of seizures such as are associated with epilepsy. The compounds of the invention exhibit an improved therapeutic ratio, relative to valproic acid, with regard to sedation and teratogenic potential, and exhibit improved pharmacokinetics and pharmacodynamics.

L'invention concerne des 2-fluoro-2-alkyl alkanoamides représentés par la formule I, et les compositions pharmaceutiques les contenant. Ces composés et ces compositions sont utiles pour traiter et prévenir des crises telles que celles associées à l'épilepsie. Les composés de l'invention présentent un rapport thérapeutique amélioré par rapport à l'acide valproïque, en ce qui concerne les effets sédatifs et le potentiel tératogène. Ils présentent également une phamacocinétique et une pharmacodynamie améliorées.

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