2-fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors

Details 2-fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors 2-fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2706946

Pyrazolo[1,5-a]pyrimidine-based inhibitors of various kinase, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions that contain such inhibitors are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 or CHK-1 inhibitor compounds, methods of inhibiting CDK-2 or CHK-1, and methods for treating disease or disease symptoms.

L'invention concerne des inhibiteurs à base de pyrazolo[1,5-a]pyrimidine de diverses kinases, des compositions comprenant les inhibiteurs, et des procédés d'utilisation d'inhibiteurs et de compositions d'inhibiteur. Les inhibiteurs et les compositions qui contiennent de tels inhibiteurs sont utiles pour traiter une maladie ou des symptômes de maladie. L'invention concerne également des procédés de fabrication de composés inhibiteurs de CDK-2 ou CHK-1, des procédés d'inhibition de CDK-2 ou CHK-1, et des procédés pour traiter une maladie ou des symptômes de maladie.

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