C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
167/179, 260/291
C07F 9/38 (2006.01) A61K 31/66 (2006.01) C07F 9/40 (2006.01) C07F 9/547 (2006.01)
Patent
CA 2032772
2-Formylbenzylphosphonic acid derivatives, their prepar- ation and their use for the treatment of diseases caused by viruses The compound of the formula I Image in which R is an aldehyde group or a group which can be converted into an aldehyde, R1 and R2 are alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, hydrogen, sodium, potas- sium, calcium, magnesium, aluminum, lithium, ammonium or triethylammonium, or R1 and R2 together form a cyclic diester, R3 and R4 are alkyl, alkenyl, alkynyl, cycloalkyl, hydro- gen, alkoxy or halogen, R5 and R8 are alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, alkoxy, phenyl, cyanide, hydroxyl or hydrogen, and X, Y or Z are oxygen or sulfur, or prodrug forms of the compound of the formula I can be used for the treatment of diseases caused by viruses. The preparation of these compounds and pharmaceutical preparations containing them and their use is described.
Helsberg Matthias
Meichsner Christoph
Peyman Anuschirwan
Uhlmann Eugen
Winkler Irvin
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
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