2-guanidino-4-aryl-quinazoline

Details 2-guanidino-4-aryl-quinazoline 2-guanidino-4-aryl-quinazoline

C - Chemistry, Metallurgy

07

D

C07D 239/84 (2006.01) A61K 31/517 (2006.01) A61P 7/02 (2006.01)

Patent

CA 2421222

The invention relates to compounds of formula (I), wherein Y represents (II) or (III) and Ar, R1, R2, R5, R6, R7 and R8 have the above-mentioned meaning, in addition to the salts and solvates thereof and the use thereof as NHE-3- inhibitors.

L'invention concerne des composés de formule (I), dans laquelle Y signifie (II) ou (III) et Ar, R?1¿, R?2¿, R?5¿, R?6¿, R?7¿ et R?8¿ ont les significations indiquées, ainsi que leurs sels et solvates, et leur utilisation en tant qu'inhibiteurs de NHE-3.

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