2-guanidino-4-heterocyclylquinazolines

Details 2-guanidino-4-heterocyclylquinazolines 2-guanidino-4-heterocyclylquinazolines

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/517 (2006.01) A61P 13/12 (2006.01) C07D 213/50 (2006.01) C07D 239/84 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 407/04 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2470030

The invention relates to compounds of formula (I): where (Y) = formula (I) or formula (III) and Het, R1, R2, R5, R6, R7 and R8 have the given meanings, the salts and solvates and the use thereof as NHE-3 inhibitors.

La présente invention concerne des composés de formule (I) dans laquelle Y se caractérise par la formule (II) ou (III) et Het, R?1¿, R?2¿, R?5¿, R?6¿, R?7¿ et R?8¿ correspondent aux éléments indiqués, leurs sels et solvates, et leur utilisation en tant qu'inhibiteurs de NHE-3.

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