2-guanidinothiazole derivatives

Details 2-guanidinothiazole derivatives 2-guanidinothiazole derivatives

C - Chemistry, Metallurgy

07

D

260/302, 260/310

C07D 277/38 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1158243

2-GUANIDIMITHIAZOLE DERIVATIVES Abstract: A compound of the formula: Image [wherein n is an integer from 2 to 4; R is hydrogen, C1-C6 alkyl (optionally substituted by hydroxy, cyano, amino, or phenoxy), C3-C6 cyclonlkyl, C2-C6 alkenyl (optionally substituted by phenyl or C2-C7 alkoxycarbonyl), C4-C7 alkadienyl, C6-C12 aryl (optionally substituted by one to three members selected from halogen, cyano, nitro, amino, C2-C10 dialkylamino, tetrazolyl, hydroxy, C1-C6 alkoxy, benzoyloxy, C2-C7 alkoxycarbonyl, sulfamoyl, C1-C6 alkyl- sulfonyl, C1-C6 alkanesulfonamido, and C1-C6 alkanoyl), or 5- or 6-membered heterocycle (optionally substituted by halogen, C1-C6 alkyl, or phenyl); and X is a single bond or thia] and its pharmaceutically acceptable acid addition salts, being useful as anti-peptic ulcer agents or histamine H2 receptor antagonists.

376153

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