2-heteroaryl-5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]dia...

Details 2-heteroaryl-5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]dia... 2-heteroaryl-5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]dia...

C - Chemistry, Metallurgy

07

D

C07D 471/14 (2006.01) A61K 31/55 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2183571

Disclosed are novel 2-heteroaryl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'- e][1,4]diazepines of formula (1), wherein Z is an oxygen or sulfur atom, =NCN or a group of the formula =NOR10 wherein R10 is alkyl of 1 to 3 carbon atoms; Ar is a group of formulae (I, II, III, IV or V). These compounds are useful in the prevention or treatment of HIV infections.

La présente invention porte sur de nouvelles 2-hétéroaryl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4] diazépines de la formule (1), dans laquelle Z représente un atome d'oxygène ou de soufre, =NCN ou un groupe de la formule =NOR?10¿ dans laquelle R?10¿ représente alkyle de 1 à 3 atomes de carbone; Ar représente un groupe de la formule (I, II, III, IV ou V). Ces composés sont utiles pour la prévention ou le traitement des infections à VIH.

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