2-heteroarylamino-pyrimidine derivatives as kinase inhibitors

Details 2-heteroarylamino-pyrimidine derivatives as kinase inhibitors 2-heteroarylamino-pyrimidine derivatives as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2697077

The invention provides compounds of Formula (I) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFR.alpha., PDGFR.beta., CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGF.beta., SRC, EGFR, trkB, FGFR3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK20, BRK, Fms, KDR, c-raf or b-raf kinases.

L'invention concerne des composés de formule (I) et des compositions pharmaceutiques de ceux-ci, qui sont utiles en tant qu'inhibiteurs de protéine kinase, ainsi que des procédés d'utilisation de tels composés pour traiter, améliorer ou prévenir une affection associée à une activité de kinase anormale ou dérégulée. Dans certains modes de réalisation, l'invention propose des procédés d'utilisation de tels composés pour traiter, améliorer ou prévenir des maladies ou troubles qui impliquent une activation anormale des kinases c-kit, PDGFRa, PDGFRß, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGFß, SRC, EGFR, trkB, FGFR3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2ß, BRK, Fms, KDR, c-raf ou b-raf.

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