2-heterocyclic-5-hydroxy-1,3-pyrimidines useful as...

Details 2-heterocyclic-5-hydroxy-1,3-pyrimidines useful as... 2-heterocyclic-5-hydroxy-1,3-pyrimidines useful as...

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/505 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2139731

The present invention is novel compounds which are 2-heterocyclic-4,6- ditertiarybutyl-5-hydroxy-1,3-pyrimidines, where heterocyclic is selected from imidazole, thiazole, and oxazole, and pharmaceutically acceptable additional salts, bases, and base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of, for example, preferably inflammation.

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