2-heterocyclicalkyl-3,3a,4,5,6,7-hexahydro-3-phenyl-7-(pheny...

Details 2-heterocyclicalkyl-3,3a,4,5,6,7-hexahydro-3-phenyl-7-(pheny... 2-heterocyclicalkyl-3,3a,4,5,6,7-hexahydro-3-phenyl-7-(pheny...

C - Chemistry, Metallurgy

07

D

260/266.5, 260/2

C07D 231/56 (2006.01) C07C 45/74 (2006.01) C07D 295/13 (2006.01) C07D 403/06 (2006.01)

Patent

CA 1076575

Abstract The invention provides compounds of the formula Image wherein X1 and X2 are the same or different and are hydro- gen, F, Cl, lower alkyl, lower alkoxy or CF3; R is hydrogen or lower alkyl, A is a straight or branched chain alkylene group of from 2 to 8 carbons, and B is a 5-, 6-, or 7-mem- bered heterocyclic ring which includes a nitrogen atom and optionally includes one other heteroatom selected from the group consisting of sulfur, nitrogen and oxygen; and N-oxides and pharmaceutically acceptable acid addition salts thereof and a process for preparing these compounds which are useful as antiinflammatory agents.

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