C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/36 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07D 213/38 (2006.01) C07D 213/40 (2006.01) C07D 213/61 (2006.01) C07D 213/73 (2006.01) C07D 213/81 (2006.01) C07D 213/89 (2006.01) C07D 231/12 (2006.01) C07D 233/54 (2006.01) C07D 233/64 (2006.01) C07D 237/08 (2006.01) C07D 239/26 (2006.01) C07D 241/12 (2006.01) C07D 241/16 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01)
Patent
CA 2122633
Compounds of formula (I), wherein A represents C = C, S or O; Q represents a 5- or 6-membered unsaturated heterocyc- ling ring having a nitrogen atom in the position adjacent to the point of attachment, 0-3 further heteroatoms selected from N, O and S, and substituents R6 and R7; R1 represents H or C1-6alkyl; R2 represents H, C1-6alkyl, C3-6alkenyl, C3-6alkynyl, C3-6cycloalkyl or NH2CH2CO-; in addition, R1 and R2 taken together may form a C3-5alkylene chain; R3 represents H, C1-6alkyl, C3-6alkenyl; C3-6alkynyl; R4 and R5 independently represent H, OH, C1-6 alkoxy, C1-6 alkyl, halogen, trifluorome- thyl or NR8R9; R6 and R7 independently represent H, OH, C1-6 alkoxy, C1-6 alkyl, halogen, trifluoromethyl, C1-6 hydroxyal- kyl, amidino, CONH2 or NR8R9; in addition, R6 and R7 may independently represent O when substituted on N; R8 and R9 independently represent H or C1-6 alkyl; with various provisos; and pharmaceutically acceptable derivatives thereof; are useful as pharmaceuticals, in particular in the treatment of neurological disorders.
Griffith Ronald Conrad
Murray Robert John
Schmiesing Richard John
Astra Ab
Fisons Corporation
Ridout & Maybee Llp
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