C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/22 (2006.01) C07D 311/56 (2006.01)
Patent
CA 2497584
The present invention provides 2-heterosubstituted 3-aryl-4H-benzopyran-4-one compounds for the treatment of cancers, namely breast cancer. This invention further provides a method of synthesis of 2-(alkylthio)isoflavones that can be carried out at ambient conditions. This invention further provides a method of synthesis of the 2-heterosubstituted 3-aryl-4H-benzopyran-4-one from a 2- (alkylthio)isoflavone. The invention further provides methods of using the 2- heterosubstitured 3-aryl-4H-benzopyran-4-one compounds for the treatment of breast cancer in mammals.
L'invention se rapporte à des composés 3-aryl-4H-benzopyran-4-one hétérosubstitués en position 2 qui servent à traiter le cancer, notamment le cancer du sein. Cette invention concerne en outre un procédé permettant de synthétiser des 2-(alkylthio)isoflavones à des conditions ambiantes. La présente invention se rapporte également à un procédé de synthèse de 3-aryl-4H-benzopyran-4-one hétérosubstituée en position 2 à partir d'une 2-(alkylthio)isoflavone. L'invention concerne par ailleurs des procédés d'utilisation desdits composés 3-aryl-4H-benzopyran-4-one hétérosubstitués en position 2 pour traiter un cancer du sein chez des mammifères.
Brueggemeier Robert
Kim Young-Woo
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
The Ohio State University Research Foundation
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