2-hydroxy-3-phenoxypropyl-substituted piperazines and...

Details 2-hydroxy-3-phenoxypropyl-substituted piperazines and... 2-hydroxy-3-phenoxypropyl-substituted piperazines and...

C - Chemistry, Metallurgy

07

D

167/210, 167/223

C07D 295/04 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 295/092 (2006.01)

Patent

CA 1337653

Disclosed are 2-hydroxy-3-phenoxypropyl-substi- tuted piperazines and homopiperazines of the formula I: Image I where R1 and R2 are hydrogen, fluorine or chlorine, methoxy, methyl or trifluoromethyl, R3, R4 and R5 are hydrogen, fluorine or chlorine, methyl, trifluoromethyl, cyano or nitro or a saturated or unsaturated alkoxy of up to 3 carbon atoms, Y is oxygen or sulfur, m is 1, 2 or 3, and n is 2 or 3. These compounds, xome of which are new, improve the regional blood supply in the brain and thus are useful for the therapy of hyproxic and ischemic states and other acute and chronic oxygen deficiency in the brain of a patient.

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