2-hydroxy- and 2-acyloxy-4-morpholinyl anthracyclines

Details 2-hydroxy- and 2-acyloxy-4-morpholinyl anthracyclines 2-hydroxy- and 2-acyloxy-4-morpholinyl anthracyclines

C - Chemistry, Metallurgy

07

H

C07H 15/252 (2006.01) A61K 31/70 (2006.01) C07H 19/24 (2006.01)

Patent

CA 2088979

2088979 9204362 PCTABS00011 Anthracycline glycosides of formula (1) wherein R1 is hydrogen or methoxy group; R2 is hydrogen or hydroxy; both R3 and R4 represent hydrogen or one of R3 and R4 is hydroxy and the other of R3 and R4 represents hydrogen; R5 represents hydrogen atom or an acyl residue -COX in which X is a C1-C8 linear or branched alkyl chain, an aryl, an aryl lower alkyl, or a 5- or 6-membered heteroaromatic group are anti-tumour agents.

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