C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 335/08 (2006.01) A61K 31/17 (2006.01) A61P 29/00 (2006.01) C07C 335/10 (2006.01) C07C 335/14 (2006.01)
Patent
CA 2439838
Compounds of formula (i) and of formula (ii), wherein the symbols have the meaning disclosed in the claims, specifically or selectively modulate .alpha.2A adrenergic receptors and as such are useful for alleviating chronic pain and allodynia and have no or only minimal cardiovascular and/or sedatory activity. The invention also relates to a method of activating .alpha.2B or .alpha.2C adrenergic receptors in a mammal by administering a compound that has .alpha.2Bor .alpha.2C adrenergic receptor activity and has no significant .alpha.2A agonist activity.
L'invention concerne des composés de formule (i) et de formule (ii), dans lesquelles les symboles ont la signification indiquée dans la spécification, des récepteurs adrénergiques .alpha.¿2B? et/ou .alpha.¿2C? spécifiquement ou sélectivement modulés, de préférence sur des récepteurs adrénergiques .alpha.¿2A? ?. Ces composés servent à alléger les douleurs chroniques et l'allodynie et présentent une activité cardiovasculaire et/ou sédative nulle voire seulement minimale.
Chow Ken
Fang Wenkui Ken
Garst Michael E.
Gil Daniel W.
Allergan Inc.
Gowling Lafleur Henderson Llp
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